CEQUEL is a randomised clinical trial of treatment for bipolar depression. The trial is comparing combination therapy with quetiapine plus lamotrigine with quetiapine monotherapy for treatment of bipolar depression.

CEQUEL will also:

• investigate the effect of adding folic acid to other treatments for bipolar depression
• find out which of the treatments best helps people to remain well after an episode of depression
• look for genetic factors that affect response to folic acid

The trial is being undertaken by the Oxford Clinical Trials Unit for Mental Illness (OCTUMI) as a collaboration between the University of Oxford Department of Psychiatry and the Centre for Statistics in Medicine.

Visit the site at www.cequel.org